Aside from the perfect timing that is required to perform the two skips, this run itself wasn't too hard to manage, but the game continuously froze during the cutscene before the Tyrant room when it was played on the Playstation 2 (SCPH-70012), so after multiple freezes, I was forced to play on PSX (SCPH-9001) without the Fast Disc Speed to support the run. 

I was a little disappointed to have taken damage during the Tyrant fight - ran outward a little too far which gave him time to catch up to Jill and avoid being stuck on Wesker.

This time probably wouldn't have been possible on PSX without the Barry and Serum Skips, so huge thanks to TheMixedHerb and SephJul. Also, thanks to Carcinogen for helping me with the encoding progress. It feels good to have two records under the belt (the other being Resident Evil 3: Nemesis), though, this run still has lots of room for improvement.